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Sep 27 2023
Classes and Applications of Cell-Penetrating Peptides
Classes of Cell-Penetrating Peptides There are many types of cell-penetrating peptides (CPPs) , and their classification is based on physicochemical properties, sources, intake mechanisms, and biomedical applications. There is no unified conclusion yet. According to their physical and chemical properties, CPPs can be divided into three types: cationic, amphiphilic and hydrophobic, among which cationic and amphiphilic CPPs are dominant, accounting for about 85%, while hydrophobic CPPs account..
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Aug 30 2023
FDA Approved Peptide Drugs in the First Half of 2023
The FDA's Center for Drug Evaluation and Research (CDER) regulatory approval of a total of 26 NME (New Molecular Entity) drugs in the first half of 2023. It is worth noting that the 26 drugs approved include 4 peptide drugs, accounting for 15% of the total. In the past 2022, the FDA has approved only three peptide drugs: Tirzepatide, Lutetium 177Lu Vipivotide Tetraxetan and Terlipressin, of which terlipressin was previously available outside the United States as Glypressin®. There is als..
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Jul 25 2023
Cell Penetrating Peptides: Definition and Synthesis
What are c ell p enetrating p eptides ? Cell Penetrating Peptides (CPPs) are short peptides that have the ability to cross biological membranes and enter cells. They are able to traverse the cell membrane by directly translocating across the lipid bilayer or by exploiting endocytic pathways. CPPs are generally composed of 5-30 amino acids and are known for their high cell-penetrating efficiency and low toxicity. They can transport a wide variety of cargo molecules, such as small molecules, p..
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Jul 25 2023
Microbial Fermentation -- a Cost Effective Way to Obtain Peptides
Peptides are short chains of amino acids that have various biological activities and therapeutic potential. They play crucial roles in various biological processes, such as cell signaling, enzyme activity regulation, and immune response modulation. Peptide fermentation allows for the production of peptides in sufficient quantities to meet the demands of research, clinical trials, and commercialization. It offers several advantages over traditional chemical synthesis methods, including cost-e..
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